​Pharmacology - Lubiprostone

​Pharmacology - Lubiprostone 
The action of lubiprostone 
Increases the amount of fluid that is present in the gut, which helps in the movement of the digestive tract.

Method of Operation 
The apical membrane of the gastrointestinal epithelium is activated, which results in the activation of the CIC-2 chloride channel.
The increased secretion of chloride ion is accompanied by water, which results in an increase in the amount of fluid that is found inside the lumen.

Ingestion of the medication. Only a small amount of the substance is absorbed by the body as a whole.

Use in Clinical Settings 
Chronic constipation is a common condition. Constipation and irritable bowel syndrome going hand in hand.

Adverse Effects 
Nausea is it. There is diarrhea.