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Pharmacology - Mercaptopurine
Action of Mercaptopurine
Purine analogue that inhibits purine synthesis and gives birth to a false nucleotide. delivered verbally. Keep in mind that the immunosuppressive medication azathioprine is metabolized to mercaptopurine. Adenosine deaminase, which is critical for the production of inosine at the beginning of ribonucleic acid synthesis, is inhibited by pentostatin, another purine analogue.
Application in Clinical Practice
Both chronic myeloid leukemia and acute leukemias.
Negative Outcomes
Myelosuppression, hepatotoxicity, immunosuppression. GIT ulcers and pancreatitis are uncommon.
Action of Mercaptopurine
Purine analogue that inhibits purine synthesis and gives birth to a false nucleotide. delivered verbally. Keep in mind that the immunosuppressive medication azathioprine is metabolized to mercaptopurine. Adenosine deaminase, which is critical for the production of inosine at the beginning of ribonucleic acid synthesis, is inhibited by pentostatin, another purine analogue.
Application in Clinical Practice
Both chronic myeloid leukemia and acute leukemias.
Negative Outcomes
Myelosuppression, hepatotoxicity, immunosuppression. GIT ulcers and pancreatitis are uncommon.
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