Pharmacology - Mirtazapine
Antidepressant medication mirtazapine. Method of Operation Since it acts as an antagonist at presynaptic alpha 2-adrenoceptors, it prevents the inhibitory impact of noradrenaline on 5-HT and maybe also on the release of noradrenaline from neurons in the central nervous system, which ultimately results in an increase in monoaminergic transmission. Antagonism of 5-HT2 and 5-HT3 receptors may be advantageous in minimizing the adverse effects that are caused by the potentiation of serotonergic transmission. For example, the sexual dysfunction and nausea that are caused by uptake inhibitors can be mitigated through the use of antagonism. Use in Clinical Settings The most severe depression. The illness known as post-traumatic stress. Effects That Are Bad Although it does not have many of the negative effects that are associated with muscarinic or adrenoceptor block, it does have antihistamine properties, such as sedation, which might be helpful in cases when insomnia is part of the depression. Increased hunger and weight gain are both symptoms. Although uncommon, agranulocytosis is a dangerous condition.
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