​Pharmacology - Montelukast

​Pharmacology - Montelukast 
One of the effects of Montelukast is to reverse bronchoconstriction. During mild asthma, it relaxes the smooth muscle of the airway.

Mode of Action
As an antagonist, the medication acts on the cysteinyl leukotriene receptor, also known as CysLT1, which is the receptor on which the bronchospasmic mediators LTC4, LTD4, and LTE4 are active. When an allergen is breathed, it can trigger both the early-phase and the late-phase responses. Children are able to take it easily. 

Orally administered. A half-life of three to five hours; metabolized in the liver and primarily eliminated in bile.

Use in Clinical Settings 
A medicine that is used as an adjuvant to inhaled corticosteroids and long-acting beta 2-agonists, it is considered a third-line treatment for asthma. Proven to be effective in asthma caused by aspirin.

Negative Effects Are Rare.