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Pharmacology - Nifedipine
The arterial resistance vessels and coronary arteries are dilated and relaxed, which results in a reduction in the amount of work that the heart has to do and the metabolic demand, as well as an increase in the perfusion and oxygenation of the heart muscle.
Mode of Action
Inhibits calcium channels that are voltage-gated and slows down the contractile process simultaneously;
Orally administered. For nifedipine, the elimination half-life is around two hours, for amlodipine it is approximately forty hours, for verapamil it is six hours, and for diltiazem it is four hours.
Use in Clinical Settings
(Nifedipine and diltiazem) in order to prevent angina pain. Regarding hypertension;
Adverse Reactions
Symptoms of nifedipine include flushing and headaches, and with chronic use, swelling of the ankles.
The arterial resistance vessels and coronary arteries are dilated and relaxed, which results in a reduction in the amount of work that the heart has to do and the metabolic demand, as well as an increase in the perfusion and oxygenation of the heart muscle.
Mode of Action
Inhibits calcium channels that are voltage-gated and slows down the contractile process simultaneously;
Orally administered. For nifedipine, the elimination half-life is around two hours, for amlodipine it is approximately forty hours, for verapamil it is six hours, and for diltiazem it is four hours.
Use in Clinical Settings
(Nifedipine and diltiazem) in order to prevent angina pain. Regarding hypertension;
Adverse Reactions
Symptoms of nifedipine include flushing and headaches, and with chronic use, swelling of the ankles.
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