Pharmacology - Praziquantel
Praziquantel Action It produces an increase in the calcium permeability of the cell membranes, facilitating calcium inux, resulting in prolonged contraction of muscle with eventual paralysis and death Mode of Action Given orally, well absorbrd, metabolised to inactive products. Plasma half-life 60–90min. Use in Clinical Settings Schistosomiasis, cysticercosis. Precautions to Take Few and minor: sometimes GIT disruptions.
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