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Pharmacology - Praziquantel
Praziquantel Action
It produces an increase in the calcium permeability of the cell membranes, facilitating calcium in€ux, resulting in prolonged contraction of muscle with eventual paralysis and death
Mode of Action
Given orally, well absorbrd, metabolised to inactive products. Plasma half-life 60–90min.
Use in Clinical Settings
Schistosomiasis, cysticercosis.
Precautions to Take
Few and minor: sometimes GIT disruptions.
Praziquantel Action
It produces an increase in the calcium permeability of the cell membranes, facilitating calcium in€ux, resulting in prolonged contraction of muscle with eventual paralysis and death
Mode of Action
Given orally, well absorbrd, metabolised to inactive products. Plasma half-life 60–90min.
Use in Clinical Settings
Schistosomiasis, cysticercosis.
Precautions to Take
Few and minor: sometimes GIT disruptions.
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