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Pharmacology - Proguanil
An action of the slow blood schizonticide
Action Process
Prevents the malaria parasite from producing thymidylate by blocking its enzyme, dihydrofolate reductase (DHFR).
Orally administered, the half-life is sixteen hours.
Medical Application
To prevent malaria, typically in conjunction with chloroquine.
In certain areas, proguanil + atovaquone is utilized for both falciparum malaria therapy and chemoprophylaxis.
Potential Side Effects
Very few because the medicine does not block the host's DHFR. Uncommon: gastrointestinal (GI) issues, redness, oral ulcers, thinning hair.
An action of the slow blood schizonticide
Action Process
Prevents the malaria parasite from producing thymidylate by blocking its enzyme, dihydrofolate reductase (DHFR).
Orally administered, the half-life is sixteen hours.
Medical Application
To prevent malaria, typically in conjunction with chloroquine.
In certain areas, proguanil + atovaquone is utilized for both falciparum malaria therapy and chemoprophylaxis.
Potential Side Effects
Very few because the medicine does not block the host's DHFR. Uncommon: gastrointestinal (GI) issues, redness, oral ulcers, thinning hair.
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