Pharmacology - Quinine

Pharmacology - Quinine 
How Quinine Works 
An effective medication against malaria parasites in RBCs, known as a schizonticidal medicine.
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Mode of Action 
Theoretically, it protects the parasite from haem by blocking the enzyme that ordinarily breaks it down. The parasite is killed when the poisonous haem molecules build up.

When administered orally, the half-life is 10 hours; however, it can also be administered intravenously. Parasitic red blood cells are where it partially accumulates. Liver metabolism results in a half-life of 10 hours.

Application in Clinical Practice 
In order to alleviate severe cases of parasitic malaria (P. falciparum). Doxycycline, clindamycin, or pyrimethamine plus sulfadoxine are common administration sequences. Not a good candidate for chemoprevention.

Potential Side Effects 
gastrointestinal issues, ringing in the ears, and visual headaches. Syncope, hypotension, and central nervous system abnormalities can occur with high dosages. The side effects of quinine include black water fever, which can be caused by intravascular hemolysis, hemoglobinuria, and kidney failure.