​Pharmacology - Rifampicin

​Pharmacology - Rifampicin 
Rifampicin kills mycobacteria and a wide variety of other bacteria, including many Gram-negative and most Gram-positive ones.

Action Process
 Inhibits DNA-dependent RNA polymerase, which reduces bacterial RNA synthesis but has no effect on human cells.
Upon oral administration, it is dispersed throughout the body and eliminated through the kidneys and urine. The effectiveness of anticoagulants, narcotic analgesics, phenytoin, glucocorticoids, and oral contraceptives is diminished when metabolizing enzymes are activated.

Application in Clinical Practice
Chest disease (when used together other medications). The disease of leprosy. Disease prevention against Haemophilus influenzae and meningococcal meningitis. Used in conjunction with other medications to treat severe staphylococcal infections, legionnaires' disease, endocarditis, and brucellosis.

Risk of Side Effects
 Irritation of the gastrointestinal tract, hepatitis, rash, and a slightly orange hue to perspiration and tears. The development of influenza-like symptoms, respiratory issues, shock, renal problems, and thrombocytopenic purpura might occur in patients whose treatment is intermittent.