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Pharmacology - Saquinavir
This reversible inhibitor blocks the viral-specific protease, which is responsible for cleaving precursor viral proteins during budding and assembly to produce the structural and functional proteins of newly formed virions.
Acute first-pass metabolism occurs after oral administration. Half life is 12 hours.
Use in Clinical Settings
infection with HIV-1 while taking other antiretrovirals (ARTs). The virus can be reduced by around 50% when passed from mother to foetus.
Negative Impacts
difficulties with the gastrointestinal tract, sinusitis, insulin resistance, and lipodystrophy.
This reversible inhibitor blocks the viral-specific protease, which is responsible for cleaving precursor viral proteins during budding and assembly to produce the structural and functional proteins of newly formed virions.
Acute first-pass metabolism occurs after oral administration. Half life is 12 hours.
Use in Clinical Settings
infection with HIV-1 while taking other antiretrovirals (ARTs). The virus can be reduced by around 50% when passed from mother to foetus.
Negative Impacts
difficulties with the gastrointestinal tract, sinusitis, insulin resistance, and lipodystrophy.
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