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Pharmacology – Terbinafine
Terbinafine's fungicidal action stems from its inhibition of ergosterol synthesis, a critical component of fungal cell membranes that is absent in mammalian cells.
Method of Operation
inhibits the enzyme that converts squalene to lanostreol, squalene epoxidase.
When taken orally, it absorbs into the fat, nails, and skin. Can be given topically.
Application in Clinical Practice
Fungal infections of the skin and nails, also known as "ringworm" (tinea corporis, tinea cruris, and tinea pedis)
Adverse Reactions GIT disturbances; headache, dizziness, rash.
Terbinafine's fungicidal action stems from its inhibition of ergosterol synthesis, a critical component of fungal cell membranes that is absent in mammalian cells.
Method of Operation
inhibits the enzyme that converts squalene to lanostreol, squalene epoxidase.
When taken orally, it absorbs into the fat, nails, and skin. Can be given topically.
Application in Clinical Practice
Fungal infections of the skin and nails, also known as "ringworm" (tinea corporis, tinea cruris, and tinea pedis)
Adverse Reactions GIT disturbances; headache, dizziness, rash.
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