Pharmacology - Verapamil

Pharmacology - Verapamil 
Verapamil is an anti dysrhythmic agent. This substance is also antihypertensive and antianginal. With the ability to block Ca2+ channels in cardiac muscle as well as smooth muscle, this compound possesses both negative inotropic and smooth muscle relaxant properties.
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 Mode of action
Verapamil blocks voltage-gated Ca2+ channels of the L-type, which play a significant role in the action potential plateau and, in particular, influence the propagation of action potentials in the SA and AV nodes. Exhibits a reliance on use, making it more active in tachyarrhythmia disorders. The automaticity is reduced, and the AV conduction is slowed down.

Oral administration (sometimes intravenous administration) . Half life between six and eight hours.

Use in Clinical Settings 
supraventricular tachycardias are conditions that occur. Atrial fibrillation allows for the regulation of the ventricular rate.

Adverse Effects 
Hypotension and dizziness, ankle oedema, and constipation are some of the side effects that might occur as a result of smooth muscle relaxation. Both heart block and bradycardia are examples of undesirable cardiac interventions.