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Symptoms and Signs – Differential Diagnosis of B12 deficiency
Reduced Absorption
Reduced Intrinsic factor (pernicious anaemia, gastrectomy)
Terminal ileal surgery/disease (coeliac disease, Crohn's disease, tuberculosis,
bacterial overgrowth, lymphoma, tropical sprue, fish tapeworm)
Drug-induced malabsorption, e.g. metformin
Reduced intake (vegans)
Transcobalmin deficiency (congenital), nitrous oxide (inactivates 812)
Reduced Absorption
Reduced Intrinsic factor (pernicious anaemia, gastrectomy)
Terminal ileal surgery/disease (coeliac disease, Crohn's disease, tuberculosis,
bacterial overgrowth, lymphoma, tropical sprue, fish tapeworm)
Drug-induced malabsorption, e.g. metformin
Reduced intake (vegans)
Transcobalmin deficiency (congenital), nitrous oxide (inactivates 812)
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