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Symptoms and Signs - Differential Diagnosis of Bone Lesions, Preferential Site of Origin EPIPHYSIS • Chondroblastoma • Giant cell tumor—after fusion of growth plate • Langerhans cell histiocytosis • Clear cell chondrosarcoma • Osteosarcoma METAPHYSIS • Parosteal sarcoma • Chondrosarcoma • Fibrosarcoma • Nonossifying fibroma • Giant cell tumor—before fusion of growth plate • Unicameral bone cyst • Aneurysmal bone cyst DIAPHYSIS • Myeloma • Ewing’s tumor • Reticulum cell sarcoma METADIAPHYSEAL • Fibrosarcoma • Fibrous dysplasia • Enchondroma • Osteoid osteoma • Chondromyofibroma 
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