​Symptoms and Signs – Differential Diagnosis of Chronic Fatigue Syndrome

​Symptoms and Signs – Differential Diagnosis of Chronic Fatigue Syndrome
• Autoimmune diseases: systemic lupus erythematosus (SLE), myasthenia gravis, multiple sclerosis, thyroiditis, rheumatoid arthritis (RA)
• Endocrine abnormalities: hypothyroidism, hypopituitarism, adrenal insufficiency, Cushing’s syndrome, diabetes mellitus (DM), hyperparathyroidism, pregnancy, reactive hypoglycemia
• Infectious diseases (subacute bacterial endocarditis [SBE], Lyme disease, fungal diseases, mononucleosis, HIV infection, chronic hepatitis B or C, TB, chronic parasitic infections)
• Occult malignant disease
• Other: inadequate rest, sleep apnea, narcolepsy, fibromyalgia, sarcoidosis, medications, toxic agent exposure, Wegener’s granulomatosis
• Psychosocial depression, dysthymia, anxiety-related disorders, and other psychiatric diseases
• Substance abuse
• Systemic disorders: chronic renal failure, chronic obstructive pulmonary disease (COPD), cardiovascular disease, anemia, electrolyte abnormalities, liver disease