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Symptoms and Signs – Differential Diagnosis of Complement deficiency
Congenital e.g. C1 esterase (C1 inhibitor) deficiency (normal C3, reduced C4)
Acquired
Reduced C3 and C4:
SLE, mixed cryoglobulinaemia
Subacute bacterial endocarditis
Serum sickness
Increased Loss/reduced synthesis: malnutrition, nephrotic syndrome, burns, liver failure
Reduced C3
Mesangiocapillary glomerulonephritis, partial lipodystrophy
Gram -ve (endotoxic) shock
Increased C3 and/or C4
Acute phase response
Congenital e.g. C1 esterase (C1 inhibitor) deficiency (normal C3, reduced C4)
Acquired
Reduced C3 and C4:
SLE, mixed cryoglobulinaemia
Subacute bacterial endocarditis
Serum sickness
Increased Loss/reduced synthesis: malnutrition, nephrotic syndrome, burns, liver failure
Reduced C3
Mesangiocapillary glomerulonephritis, partial lipodystrophy
Gram -ve (endotoxic) shock
Increased C3 and/or C4
Acute phase response
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