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Symptoms and Signs – Differential Diagnosis of Dermatosis by Morphology MACULES Hypopigmented • Halo nevus • Leprosy • Postinflammatory • Sarcoidosis • Tinea versicolor • Tuberous sclerosis • Vitiligo Hyperpigmented • Café au lait spot • Drug eruption • Ephelis (freckle) • Lentigo • Mastocytosis • Melanoma • Melasma • Mongolian spot • Nevus • Ochronosis • Postinflammatory • Purpura • Stasis dermatitis Erythematous • Drug eruption • Rheumatic fever • Secondary syphilis • Viral exanthem PAPULES Isolated Papules • Acrochordon • Actinic keratosis • Angiofibroma • Angioma • Appendageal tumors (benign or malignant) • Bacillary angiomatosis • Basal cell carcinoma • Chondrodermatitis nodularis helicis • Dermatofibroma • Fungal infections, early • Hemangioma • Keratoacanthoma • Melanoma • Milia • Molluscum contagiosum • Neurofibroma • Nevus • Pyogenic granuloma • Sebaceous hyperplasia • Seborrheic keratosis • Squamous cell carcinoma • Wart Papular Eruptions • Acne rosacea • Acne vulgaris • Appendageal tumors (usually benign) • Arthropod bite • Bacillary angiomatosis • Dermatomyositis • Drug eruption • Eczematous dermatitis • Flat warts • Folliculitis • Granuloma annulare • Keratosis pilaris • Lichen nitidus • Lichen planus • Lichen sclerosus • Lupus erythematosus • Lymphoma • Miliaria • Molluscum contagiosum • Neurofibromatosis • Pediculosis corporis • Perioral dermatitis • Pityriasis rosea • Polymorphous light eruption • Pruritic urticarial papules, plaques of pregnancy • Psoriasis • Sarcoidosis • Sarcoma (Kaposi’s, other) • Scabies • Syphilis • Urticaria • Vasculitis • Venous lake • Viral exanthem • Xanthoma PUSTULES • Acne rosacea/perioral dermatitis • Acne vulgaris • Arthropod bite (fire ants) • Drug eruption • Eosinophilic folliculitis • Erythema toxicum neonatorum • Folliculitis • Fungal or yeast infections, especially tinea capitis and Majocchi’s granuloma • Furunculosis • Gonorrhea, disseminated • Herpes simplex/zoster • Impetigo • Keratosis pilaris • Neonatal pustulosis • Pseudofolliculitis barbae • Pustular psoriasis • Pyoderma gangrenosum • Syphilis • Varicella PLAQUES • Acanthosis nigricans • Candidiasis • Cellulitis • Deep fungal infections • Dermatomyositis • Diaper dermatitis • Eczematous dermatitis, including lichen simplex chronicus • Erythrasma • Fungal infections (e.g., tinea corporis, pedis, cruris, manus) • Granuloma annulare • Ichthyosis • Lichen planus • Lichen sclerosus • Lupus erythematosus • Lyme disease • Lymphoma, cutaneous T-cell • Morphea • Myxedema • Necrobiosis lipoidica diabeticorum • Paget’s disease, mammary/extramammary • Pityriasis rosea • Psoriasis • Sarcoidosis • Seborrheic dermatitis • Sweet’s syndrome • Syphilis • Tinea versicolor • Vasculitis • Xanthelasma NODULES AND TUMORS • Acrochordon • Angioma • Appendageal tumors • Basal cell carcinoma • Callus/clavus • Chondrodermatitis nodularis helicis • Erythema nodosum • Hidradenitis suppurativa • Histiocytosis • Inclusion cyst • Kaposi’s sarcoma • Keloid • Lipoma • Lymphoma, cutaneous • Melanoma • Metastatic carcinoma • Neurofibroma • Nevus • Prurigo nodularis • Pyogenic granuloma • Seborrheic keratosis • Squamous cell carcinoma • Syphilis • Tuberous sclerosis • Venous lake • Wart • Xanthoma VESICLES AND BULLAE • Bullous disease in diabetes • Bullous pemphigoid • Burn • Cellulitis • Congenital syphilis • Contact dermatitis • Dermatitis herpetiformis • Eczema, especially of the hand/foot • Epidermolysis bullosa • Erythema multiforme • Fixed drug eruption • Fungal infections, especially tinea pedis • Herpes gestationis • Herpes simplex • Herpes zoster • Id reaction • Impetigo • Insect bite reaction • Lichen planus • Lupus erythematosus, bullous • Pemphigus vulgaris/foliaceus • Porphyria cutanea tarda • Scabies • Staphylococcal scalded skin syndrome • Streptococcal toxic shock–like syndrome • Toxic epidermal necrolysis • Varicella • Vasculitis EROSIONS AND ULCERS Mouth • Aphthae • Avitaminosis • Bullous pemphigoid • Burn • Candidiasis • Epidermolysis bullosa • Erythema multiforme • Hand-foot-mouth disease • Herpangina • Herpes simplex • Lichen planus • Lupus erythematosus • Pemphigus vulgaris • Perlèche • Toxic epidermal necrolysis Genital • Balanitis • Candidiasis • Chancroid • Diaper dermatitis, severe • Erythema multiforme • Fixed drug eruption • Fungal infections, tinea cruris • Herpes simplex • Intertrigo • Lichen planus • Lichen sclerosus • Lymphogranuloma venereum • Squamous cell carcinoma • Syphilis Other • Basal cell carcinoma • Bullous pemphigoid • Ecthyma • Erythema multiforme • Ischemia • Necrobiosis lipoidica • Pemphigus vulgaris • Porphyria cutanea tarda • Pyoderma gangrenosum • Spider bite • Squamous cell carcinoma • Stasis ulcer • Toxic epidermal necrosis DESQUAMATION • Exfoliative dermatitis • Kawasaki’s syndrome • Keratolysis exfoliativa (hands and feet) • Scarlet fever • Scarlatiniform eruption • Staphylococcal scalded skin syndrome • Toxic shock syndrome (late) 
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