​Symptoms and Signs – Differential Diagnosis of Granulomatous Disorders
INFECTIONS
Fungi
• Histoplasma
• Coccidioides
• Blastomyces
• Sporothrix
• Aspergillus
• Cryptococcus
Protozoa
• Toxoplasma
• Leishmania
Metazoa
• Toxocara
• Schistosoma
Spirochetes
• Treponema pallidum
• Treponema pertenue
• Treponema carateum
Mycobacteria
• Mycobacterium tuberculosis
• Mycobacterium leprae
• Mycobacterium kansasii
• Mycobacterium marinum
• Mycobacterium avium
• Bacille Calmette-Guérin (BCG) vaccine
Bacteria
• Brucella
• Yersinia
Other Infections
Cat-scratch disease
• Lymphogranuloma

NEOPLASIA
• Carcinoma
• Reticulosis
• Pinealoma
• Dysgerminoma
• Seminoma
• Reticulum cell sarcoma
• Malignant nasal granuloma

CHEMICALS
• Beryllium
• Zirconium
• Silica
• Starch
• Immunologic aberrations
• Sarcoidosis
• Crohn’s disease
• Primary biliary cirrhosis
• Wegener’s granulomatosis
• Giant cell arteritis
• Peyronie’s disease
• Hypogammaglobulinemia
• Systemic lupus erythematosus (SLE)
• Lymphomatoid granulomatosis
• Histiocytosis X
• Hepatic granulomatous disease
• Immune complex disease
• Rosenthal-Melkersson syndrome
• Churg-Strauss allergic granulomatosis
LEUKOCYTE OXIDASE DEFECT
• Chronic granulomatous disease of childhood

EXTRINSIC ALLERGIC ALVEOLITIS
• Farmer’s lung
• Bird fancier’s lung
• Mushroom worker’s lung
• Suberosis (cork dust)
• Bagassosis
• Maple bark stripper’s lung
• Paprika splitter’s lung
• Coffee bean dust
• Spatlese lung

OTHER DISORDERS
• Whipple’s disease
• Pyrexia of unknown origin
• Radiotherapy
• Cancer chemotherapy
• Panniculitis
• Chalazion
• Sebaceous cyst
• Dermoid
• Sea urchin spine injury