​Symptoms and Signs – Differential Diagnosis of Granulomatous Vasculitis
• Wegener’s granulomatosis
• Lymphomatoid granulomatosis
• Behçet’s syndrome
• Kawasaki’s disease (mucocutaneous lymph node syndrome)
PREDOMINANTLY SMALL-VESSEL DISEASE
Hypersensitivity Vasculitis (Leukocytoclastic Vasculitis)
• Henoch-Schönlein purpura
• Mixed cryoglobulinemia
• Serum sickness
• Vasculitis associated with connective tissue diseases (systemic lupus erythematosus [SLE], Sjögren’s syndrome)
• Vasculitis associated with specific syndromes: primary biliary cirrhosis, Lyme disease, chronic active hepatitis, drug-induced vasculitis
• Churg-Strauss syndrome
• Goodpasture’s syndrome
• Erythema nodosum
• Panniculitis
• Buerger’s disease (thrombophlebitis obliterans) Vasculitis, Diseases That Mimic Vasculitis
EMBOLIC DISEASE
• Infectious or marantic endocarditis
• Cardiac mural thrombus
• Atrial myxoma
• Cholesterol embolization syndrome
NONINFLAMMATORY VESSEL WALL DISRUPTION
• Atherosclerosis
• Arterial fibromuscular dysplasia
• Drug effects (vasoconstrictors, anticoagulants)
• Irradiation
• Genetic disease (neurofibromatosis, Ehlers-Danlos syndrome)
• Amyloidosis
• Intravascular malignant lymphoma
DIFFUSE COAGULATION
• Disseminated intravascular coagulation (DIC)
• Thrombotic thrombocytopenic purpura
• Hemolytic-uremic syndrome
• Protein C and S deficiencies, factor V Leiden mutation
• Antiphospholipid syndrome