- Published on
Symptoms and Signs – Differential Diagnosis of Haemolytic Anemia
Hereditary
Metabolic defects: pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency
Haemoglobinopathies: sickle cell anaemia, thalassaemia Membrane defects: spherocytosis, elliptocytosis
Acquired
Paroxysmal nocturnal haemoglobinuria, secondary to liver and renal disease
Non-immune: trauma: microangiopathic haemolytic anaemia (TIP, HUS, DIC, malignant hypertension, pre-eclampsia), artificial heart valves, March haemoglobinuria
Infection: malaria, clostridia
Drugs: penicillin, quinidine
Autoimmune: Warm antibodies (idiopathic, SLE, lymphoma, drugs, e.g. methyldopa), Cold antibodies (idiopathic, infections, e.g. Mycoplasma sp., EBV, other viruses, lymphoma)
Alloimmune: Transfusion reaction, haemolytic disease of newborn
Hereditary
Metabolic defects: pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency
Haemoglobinopathies: sickle cell anaemia, thalassaemia Membrane defects: spherocytosis, elliptocytosis
Acquired
Paroxysmal nocturnal haemoglobinuria, secondary to liver and renal disease
Non-immune: trauma: microangiopathic haemolytic anaemia (TIP, HUS, DIC, malignant hypertension, pre-eclampsia), artificial heart valves, March haemoglobinuria
Infection: malaria, clostridia
Drugs: penicillin, quinidine
Autoimmune: Warm antibodies (idiopathic, SLE, lymphoma, drugs, e.g. methyldopa), Cold antibodies (idiopathic, infections, e.g. Mycoplasma sp., EBV, other viruses, lymphoma)
Alloimmune: Transfusion reaction, haemolytic disease of newborn
0 Comments
