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Symptoms and Signs – Differential Diagnosis of Hemolysis and Hemoglobinuria
• Brown recluse spider bite
• Drugs (penicillins, quinidine, methyldopa, sulfonamides, nitrofurantoin)
• Erythrocyte enzyme deficiencies (e.g., exposure to fava beans in patients with glucose-6-phosphate dehydrogenase [G6PD] deficiency)
• Erythrocyte trauma (prosthetic cardiac valves, marching and severe trauma, extensive burns)
• Hemolytic-uremic syndrome (HUS)
• Incompatible blood transfusions
• Infections (malaria, Bartonella, Clostridium welchii)
• Paroxysmal nocturnal hemoglobinuria (PNH)
• Thrombotic thrombocytopenic purpura (TTP)
• Brown recluse spider bite
• Drugs (penicillins, quinidine, methyldopa, sulfonamides, nitrofurantoin)
• Erythrocyte enzyme deficiencies (e.g., exposure to fava beans in patients with glucose-6-phosphate dehydrogenase [G6PD] deficiency)
• Erythrocyte trauma (prosthetic cardiac valves, marching and severe trauma, extensive burns)
• Hemolytic-uremic syndrome (HUS)
• Incompatible blood transfusions
• Infections (malaria, Bartonella, Clostridium welchii)
• Paroxysmal nocturnal hemoglobinuria (PNH)
• Thrombotic thrombocytopenic purpura (TTP)
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