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Symptoms and Signs - Differential Diagnosis of Histoplasmosis
• Acute pulmonary histoplasmosis: Mycobacterium tuberculosis; community-acquired pneumonias caused by Mycoplasma and Chlamydia; other fungal diseases, such as Blastomyces dermatitidis and Coccidioides immitis
• Chronic cavitary pulmonary histoplasmosis: M. tuberculosis
• Histoplasmomas: true neoplasms
• Intracellular parasites of Leishmania and Toxoplasma species: distinguishable by inability to take up methenamine silver
• Yeast forms of histoplasmosis on tissue section: cysts of Pneumocystis jiroveci, which tend to be larger, are extracellular, and do not display budding
• Acute pulmonary histoplasmosis: Mycobacterium tuberculosis; community-acquired pneumonias caused by Mycoplasma and Chlamydia; other fungal diseases, such as Blastomyces dermatitidis and Coccidioides immitis
• Chronic cavitary pulmonary histoplasmosis: M. tuberculosis
• Histoplasmomas: true neoplasms
• Intracellular parasites of Leishmania and Toxoplasma species: distinguishable by inability to take up methenamine silver
• Yeast forms of histoplasmosis on tissue section: cysts of Pneumocystis jiroveci, which tend to be larger, are extracellular, and do not display budding
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