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Symptoms and Signs – Differential Diagnosis of Hyperuricaemia
Reduced Renal excretion
Psoriasis
Increase Synthesis: Lesch-Nyhan syndrome (HGPRT deficiency)
Increase Nucleic acid (purine) turnover: lymphoma, leukaemia, polycythaemia vera,
Increase Intake/production
Increase Dietary intake
Idiopathic
ethambutol, alcohol, pyrizinamide)
Drugs: ciclosporin, aspirin (low-dose), nicotinic acid, thiazides, loop diuretics,
Chronic renal disease, e.g. in diabetes mellitus, hypertension
Reduced Renal excretion
Psoriasis
Increase Synthesis: Lesch-Nyhan syndrome (HGPRT deficiency)
Increase Nucleic acid (purine) turnover: lymphoma, leukaemia, polycythaemia vera,
Increase Intake/production
Increase Dietary intake
Idiopathic
ethambutol, alcohol, pyrizinamide)
Drugs: ciclosporin, aspirin (low-dose), nicotinic acid, thiazides, loop diuretics,
Chronic renal disease, e.g. in diabetes mellitus, hypertension
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