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​Symptoms and Signs – Differential Diagnosis of Obstructive Uropathy 
INTRINSIC CAUSES
• Intraluminal: intratubular deposition of crystals (uric acid, sulfas), stones, papillary tissue, blood clots
• Intramural
• Functional: ureter (ureteropelvic or ureterovesical dysfunction); bladder (neurogenic): spinal cord defect or trauma, diabetes, multiple sclerosis (MS), Parkinson’s disease, cerebrovascular accidents (CVA), bladder neck dysfunction
• Anatomic: tumors, infection, granuloma, strictures
EXTRINSIC CAUSES
• Originating in the reproductive system
• Prostate: benign hypertrophy or cancer
• Uterus: pregnancy, tumors, prolapse, endometriosis
• Ovary: abscess, tumor, cysts
• Originating in the vascular system: aneurysms (aorta, iliac vessels), aberrant arteries (ureteropelvic junction), venous (ovarian veins, retrocaval ureter)
• Originating in the gastrointestinal tract: Crohn’s disease, pancreatitis, appendicitis, tumors
• Originating in the retroperitoneal space: inflammations, fibrosis, tumor, hematomas
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