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Symptoms and Signs – Differential Diagnosis of Pituitary Adenoma
PROLACTINOMA
• Pregnancy
• Postpartum puerperium
• Primary hypothyroidism
• Breast disease
• Breast stimulation
• Drug ingestion (especially phenothiazines, antidepressants, haloperidol, methyldopa, reserpine, opiates, amphetamines, and cimetidine)
• Chronic renal failure
• Liver disease
• Polycystic ovary disease
• Chest wall disorders
• Spinal cord lesions
• Previous cranial irradiation
ACROMEGALY
• Ectopic production of GH-releasing hormone from a carcinoid or other neuroendocrine tumor
CUSHING’S DISEASE
• Diseases that cause ectopic sources of ACTH overproduction (including small cell carcinoma of the lung, bronchial carcinoid, intestinal carcinoid, pancreatic islet cell tumor, medullary thyroid carcinoma, and pheochromocytoma)
• Adrenal adenomas, adrenal carcinoma
• Nelson’s syndrome
THYROTROPIN-SECRETING PITUITARY ADENOMAS
• Primary hypothyroidism
NONSECRETORY PITUITARY ADENOMA
• Non-neoplastic mass lesions of various etiologies (e.g., infectious, granulomatous)
PROLACTINOMA
• Pregnancy
• Postpartum puerperium
• Primary hypothyroidism
• Breast disease
• Breast stimulation
• Drug ingestion (especially phenothiazines, antidepressants, haloperidol, methyldopa, reserpine, opiates, amphetamines, and cimetidine)
• Chronic renal failure
• Liver disease
• Polycystic ovary disease
• Chest wall disorders
• Spinal cord lesions
• Previous cranial irradiation
ACROMEGALY
• Ectopic production of GH-releasing hormone from a carcinoid or other neuroendocrine tumor
CUSHING’S DISEASE
• Diseases that cause ectopic sources of ACTH overproduction (including small cell carcinoma of the lung, bronchial carcinoid, intestinal carcinoid, pancreatic islet cell tumor, medullary thyroid carcinoma, and pheochromocytoma)
• Adrenal adenomas, adrenal carcinoma
• Nelson’s syndrome
THYROTROPIN-SECRETING PITUITARY ADENOMAS
• Primary hypothyroidism
NONSECRETORY PITUITARY ADENOMA
• Non-neoplastic mass lesions of various etiologies (e.g., infectious, granulomatous)
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