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Symptoms and Signs- Differential Diagnosis of Platelets
Reduced Production
Bone marrow failure
Platelets 79
Myeloma, myelofibrosis, marrow infiltration (lymphoma, carcinoma), anaemia
(megaloblastic, aplastic), leukaemia
Drugs: (cytotoxics, chloramphenicol, alcohol), radiotherapy
Reduced Megakaryocytes: chemicals, drugs (e.g. co-trimoxazole), viral infection

Increased Destruction/consumption
Autoimmune (ITP)
SLE, CLL, lymphoma
Infections (malaria, viral, e.g. HIV)
Drugs (e.g. analgesics, antibiotics, anticonvulsant, anti-diabetics, heparin,
quinine, quinidine)
DIC, TIP, HUS
Sequestration: splenic pooling due to splenomegaly
Dilutional loss (massive transfusion of stored blood)
Artifactual: blood clotting in the samplep

Functional disorders
Bernard-Soulier disease
Glanzmann's thrombasthenia
Storage pool disease
Liver disease, myeloproliferative disorders, paraproteinaemia, aspirin, uraemia


Increased Platelets (thrombocytosis)
Secondary
Blood loss
Infection
Inflammation (e.g. Kawasaki's disease)
Mailgnancy (e.g. Hodgkin's disease)
Splenectomy
Trauma/surgery

Primary
Essential thrombocythaemia
Polycythaemia vera
Myelofibrosis (initially, later thrombocytopenia)
Myelodysplasia
CML


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Kembara Xtra 

Facts about medicine and its subtopic such as anatomy, physiology, biochemistry, pharmacology, medicine, pediatrics, psychiatry, obstetrics and gynecology and surgery.