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Symptoms and Signs – Differential Diagnosis of Polyneuropathy
Infection: HIV, Lyme disease, leprosy, diphtheria
Inflammation: Guillain-Barre syndrome, chronic inflammatory demyelinating
neuropathy, Sjogren's syndrome, sarcoidosis, SLE, vasculitides (e.g.
polyarteritis nodosa)
Tumours: paraneoplastic, paraproteinaemia
Toxic: alcohol, heavy metals (e.g. lead), insecticides, drugs (cisplatinum,
vincristine, amiodarone, metronidazole, phenytoin, isoniazid, nitrofurantoin,
gold)
Metabolic: diabetes mellitus, hypothyroidism, B12/thiamine deficiency,
amyloidosis, uraemia
Hereditary: e.g. abetalipoproteinaemia, porphyria, Charcot-Marie-Tooth
syndrome, Refsum's syndrome, lysosomal storage diseases, e.g. Fabry's disease,
Niemann-Pick disease
Infection: HIV, Lyme disease, leprosy, diphtheria
Inflammation: Guillain-Barre syndrome, chronic inflammatory demyelinating
neuropathy, Sjogren's syndrome, sarcoidosis, SLE, vasculitides (e.g.
polyarteritis nodosa)
Tumours: paraneoplastic, paraproteinaemia
Toxic: alcohol, heavy metals (e.g. lead), insecticides, drugs (cisplatinum,
vincristine, amiodarone, metronidazole, phenytoin, isoniazid, nitrofurantoin,
gold)
Metabolic: diabetes mellitus, hypothyroidism, B12/thiamine deficiency,
amyloidosis, uraemia
Hereditary: e.g. abetalipoproteinaemia, porphyria, Charcot-Marie-Tooth
syndrome, Refsum's syndrome, lysosomal storage diseases, e.g. Fabry's disease,
Niemann-Pick disease
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