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Symptoms and Signs – Differential Diagnosis of Purpura
Senile
Steroids (iatrogenic, Cushing's syndrome)
Infection: meningococcal septicaemia/DIC, infective endocarditis
Platelet disorders: quantitative (thrombocytopenia), qualitative (von Willebrand's
disease), coagulopathy (haemophilia, liver disease, anticoagulants) Vasculitis: e.g:
1°: Henoch-Schiinlein purpura, polyarteritis nodosa, Churg-Strauss, Wegener's granulomatosis, cryoglobulinaemia
2°: SLE, rheumatoid arthritis
Collagen diseases: scurvy, Ehlers-Danlos syndrome
Others: emboli (e.g. cholesterol), hereditary haemorrhagic telangiectasia,
Amyloidosis
Senile
Steroids (iatrogenic, Cushing's syndrome)
Infection: meningococcal septicaemia/DIC, infective endocarditis
Platelet disorders: quantitative (thrombocytopenia), qualitative (von Willebrand's
disease), coagulopathy (haemophilia, liver disease, anticoagulants) Vasculitis: e.g:
1°: Henoch-Schiinlein purpura, polyarteritis nodosa, Churg-Strauss, Wegener's granulomatosis, cryoglobulinaemia
2°: SLE, rheumatoid arthritis
Collagen diseases: scurvy, Ehlers-Danlos syndrome
Others: emboli (e.g. cholesterol), hereditary haemorrhagic telangiectasia,
Amyloidosis
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