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Symptoms and Signs – Differential Diagnosis of raised and reduced plasma concentration of creatinine
Increased Creatinine
Reduced GFR (renal failure), high muscle mass, acute muscle damage (rhabdomyolysis)
Transient/minimal increase: after exercise, high meat meal
Reduced Tubular secretion: trimethoprim, cimetidine
Reduced Creatinine
Raised GFR (pregnancy)
Low muscle mass
Increased Creatinine
Reduced GFR (renal failure), high muscle mass, acute muscle damage (rhabdomyolysis)
Transient/minimal increase: after exercise, high meat meal
Reduced Tubular secretion: trimethoprim, cimetidine
Reduced Creatinine
Raised GFR (pregnancy)
Low muscle mass
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