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Symptoms and Signs – Differential Diagnosis of Raised Homocysteine
Disease: hypothyroidism, renal failure, breast/ovarian cancer
Drugs: methotrexate, theophylline, phenytoin
Genetic: Cystathionine beta 1-synthetase deficiency, MTHFR polymorphism
Lifestyle: aging, smoking, increase coffee consumption
Vitamin deficiency: B6 , B12, folate


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