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Symptoms and Signs- Differential Diagnosis of Renal tubular acidosis
Type 1
Autoimmune: Sjogren's syndrome, SLE, primary biliary cirrhosis Nephrocalcinosis: hypercalcaemia, medullary sponge kidney Obstructive uropathy
Toxic: amphotericin, Lithium, transplanted kidney {rejection) Sickle cell anaemia
(Mnemonic: Acid NOT Secreted)
Type2
Acquired: myeloma, hyperparathyroidism, vitamin D deficiency, Drugs: acetazolamide, heavy metals
Congenital: as part of Fanconi's syndrome, fructose intolerance, cystinosis, Wilson's disease, tyrosinaemia
Type4
Diabetes mellitus Pyelonephritis
Renal tubular acidosis continued Drugs: NSAIDs, potassium-sparing diuretics Urinary obstruction
Sickle cell disease
Type 1
Autoimmune: Sjogren's syndrome, SLE, primary biliary cirrhosis Nephrocalcinosis: hypercalcaemia, medullary sponge kidney Obstructive uropathy
Toxic: amphotericin, Lithium, transplanted kidney {rejection) Sickle cell anaemia
(Mnemonic: Acid NOT Secreted)
Type2
Acquired: myeloma, hyperparathyroidism, vitamin D deficiency, Drugs: acetazolamide, heavy metals
Congenital: as part of Fanconi's syndrome, fructose intolerance, cystinosis, Wilson's disease, tyrosinaemia
Type4
Diabetes mellitus Pyelonephritis
Renal tubular acidosis continued Drugs: NSAIDs, potassium-sparing diuretics Urinary obstruction
Sickle cell disease
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