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Symptoms and Signs – Differential Diagnosis of Skin necrosis
Warfarin, Protein CJS deficiency, DIC (e.g. meningococcal septicaemia) Vasculitis (Primary: Wegener's granulomatosis, cryoglobulinaemia; Secondary:
SLE, rheumatoid arthritis)
Peripheral vascular disease
Emboli: cholesterol, subacute bacterial endocarditis
Pyoderma gangrenosum
Panniculitis (e.g. idiopathic, pancreatitis)
Calciphylaxis (small-vessel vasculitis causing skin necrosis associated with
end-stage renal failure, j Ca2+ and phosphate)
Warfarin, Protein CJS deficiency, DIC (e.g. meningococcal septicaemia) Vasculitis (Primary: Wegener's granulomatosis, cryoglobulinaemia; Secondary:
SLE, rheumatoid arthritis)
Peripheral vascular disease
Emboli: cholesterol, subacute bacterial endocarditis
Pyoderma gangrenosum
Panniculitis (e.g. idiopathic, pancreatitis)
Calciphylaxis (small-vessel vasculitis causing skin necrosis associated with
end-stage renal failure, j Ca2+ and phosphate)
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