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Symptoms and Signs – Differential Diagnosis of Splenomegaly
• Bacterial infections: TB, infectious endocarditis, typhoid fever, splenic abscess
• Collagen-vascular disorders: systemic lupus erythematosus (SLE), rheumatoid arthritis (RA; Felty’s syndrome), polyarteritis nodosa
• Gaucher’s disease and other lipid storage diseases
• Hepatic cirrhosis
• Hereditary and acquired hemolytic anemias
• Idiopathic thrombocytopenic purpura (ITP)
• Neoplastic involvement: cell-mediated lympholysis (CML), chronic lymphocytic leukemia (CLL), lymphoma, multiple myeloma
• Parasitic infections (malaria, kala-azar, histoplasmosis)
• Polycythemia vera, myeloid metaplasia
• Sarcoidosis
• Serum sickness, drug hypersensitivity reaction
• Splenic cysts and benign tumors: hemangioma, lymphangioma
• Thrombosis of splenic or portal vein
• Viral infections: infectious mononucleosis, viral hepatitis, HIV infection
• Bacterial infections: TB, infectious endocarditis, typhoid fever, splenic abscess
• Collagen-vascular disorders: systemic lupus erythematosus (SLE), rheumatoid arthritis (RA; Felty’s syndrome), polyarteritis nodosa
• Gaucher’s disease and other lipid storage diseases
• Hepatic cirrhosis
• Hereditary and acquired hemolytic anemias
• Idiopathic thrombocytopenic purpura (ITP)
• Neoplastic involvement: cell-mediated lympholysis (CML), chronic lymphocytic leukemia (CLL), lymphoma, multiple myeloma
• Parasitic infections (malaria, kala-azar, histoplasmosis)
• Polycythemia vera, myeloid metaplasia
• Sarcoidosis
• Serum sickness, drug hypersensitivity reaction
• Splenic cysts and benign tumors: hemangioma, lymphangioma
• Thrombosis of splenic or portal vein
• Viral infections: infectious mononucleosis, viral hepatitis, HIV infection
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