- Published on
Symptoms and Signs – Differential Diagnosis of Splenomegaly and Hepatomegaly
Causes of splenomegaly and hepatosplenomegaly:
MASSIVE SPLENOMEGALY
• Hematologic disease (e.g., chronic myeloid leukemia, myelofibrosis)
MODERATE SPLENOMEGALY
• The above causes
• Portal hypertension
• Hematologic disease (e.g., lymphoma, leukemia, thalassemia)
• Storage disease (e.g., Gaucher’s disease)
SMALL SPLENOMEGALY
• The above causes
• Infective (hepatitis, leptospirosis, malaria, bacterial endocarditis)
• Hematologic disease (e.g., hemolytic anemias, essential thrombocythemia, polycythemia rubra vera)
• Connective tissue diseases or vasculitis (e.g., rheumatoid arthritis, systemic lupus erythematosus, polyarteritis nodosa)
• Solitary cyst, polycystic syndrome, hydatid cyst
• Infiltration (amyloid, sarcoid)
HEPATOSPLENOMEGALY
• Chronic liver disease with portal hypertension
• Hematologic disease (e.g., myeloproliferative disease, lymphoma)
• Infection (e.g., acute viral hepatitis, infectious mononucleosis)
• Infiltration (e.g., amyloid, sarcoid)
• Connective tissue disease (e.g., systemic lupus erythematosus)
Causes of splenomegaly and hepatosplenomegaly:
MASSIVE SPLENOMEGALY
• Hematologic disease (e.g., chronic myeloid leukemia, myelofibrosis)
MODERATE SPLENOMEGALY
• The above causes
• Portal hypertension
• Hematologic disease (e.g., lymphoma, leukemia, thalassemia)
• Storage disease (e.g., Gaucher’s disease)
SMALL SPLENOMEGALY
• The above causes
• Infective (hepatitis, leptospirosis, malaria, bacterial endocarditis)
• Hematologic disease (e.g., hemolytic anemias, essential thrombocythemia, polycythemia rubra vera)
• Connective tissue diseases or vasculitis (e.g., rheumatoid arthritis, systemic lupus erythematosus, polyarteritis nodosa)
• Solitary cyst, polycystic syndrome, hydatid cyst
• Infiltration (amyloid, sarcoid)
HEPATOSPLENOMEGALY
• Chronic liver disease with portal hypertension
• Hematologic disease (e.g., myeloproliferative disease, lymphoma)
• Infection (e.g., acute viral hepatitis, infectious mononucleosis)
• Infiltration (e.g., amyloid, sarcoid)
• Connective tissue disease (e.g., systemic lupus erythematosus)
0 Comments
