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Symptoms and Signs – Differential Diagnosis of Stature
Short stature
CGPD (constitutional growth and puberty delay), familial Syndromic: Turner's syndrome, achondroplasia, Prader-Willi
Psychosocial factors: child abuse, anorexia nervosa, emotional deprivation Endocrine factors:
Reduced Growth hormone: Hypopituitarism {e.g. pituitary tumour) Mutations: Pitl, PROP1, GHRH receptor
Cushing's syndrome and ii corticosteroids
Biologically inactive GH
GH resistance (GH-receptor mutation) Low levels of IGF1 {Laron dwarfism)
Reduced thyroid l hormones {hypothyroidism)
Nutritional factors
Systemic illness:
Gastrointestinal: malabsorption {coeliac disease, milk protein intolerance, inflammatory bowel disease)
Cardiovascular: congenital cyanotic heart disease Respiratory: cystic fibrosis
Renal: chronic renal failure
Short stature
CGPD (constitutional growth and puberty delay), familial Syndromic: Turner's syndrome, achondroplasia, Prader-Willi
Psychosocial factors: child abuse, anorexia nervosa, emotional deprivation Endocrine factors:
Reduced Growth hormone: Hypopituitarism {e.g. pituitary tumour) Mutations: Pitl, PROP1, GHRH receptor
Cushing's syndrome and ii corticosteroids
Biologically inactive GH
GH resistance (GH-receptor mutation) Low levels of IGF1 {Laron dwarfism)
Reduced thyroid l hormones {hypothyroidism)
Nutritional factors
Systemic illness:
Gastrointestinal: malabsorption {coeliac disease, milk protein intolerance, inflammatory bowel disease)
Cardiovascular: congenital cyanotic heart disease Respiratory: cystic fibrosis
Renal: chronic renal failure
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