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Symptoms and Signs – Differential Diagnosis of Symmetric Polyneuropathy
ACQUIRED NEUROPATHIES
• Toxic: drugs, industrial toxins, heavy metals, abused substances
• Metabolic/endocrine: diabetes, chronic renal failure, hypothyroidism, polyneuropathy of critical illness
• Nutritional deficiency: vitamin B12 deficiency, alcoholism, vitamin E deficiency
• Paraneoplastic: carcinoma, lymphoma
• Plasma cell dyscrasia: myeloma, typical, atypical, and solitary forms; primary systemic amyloidosis
• Idiopathic chronic inflammatory demyelinating polyneuropathies
• Polyneuropathies associated with peripheral nerve autoantibodies
• AIDS
INHERITED NEUROPATHIES
• Neuropathies with biochemical markers: Refsum’s disease, Bassen- Kornzweig disease, Tangier disease, metachromatic leukodystrophy, Krabbe’s disease, adrenomyeloneuropathy,
Fabry’s disease
• Neuropathies without biochemical markers or systemic involvement: hereditary motor neuropathy, hereditary sensory neuropathy, hereditary sensorimotor neuropathy
ACQUIRED NEUROPATHIES
• Toxic: drugs, industrial toxins, heavy metals, abused substances
• Metabolic/endocrine: diabetes, chronic renal failure, hypothyroidism, polyneuropathy of critical illness
• Nutritional deficiency: vitamin B12 deficiency, alcoholism, vitamin E deficiency
• Paraneoplastic: carcinoma, lymphoma
• Plasma cell dyscrasia: myeloma, typical, atypical, and solitary forms; primary systemic amyloidosis
• Idiopathic chronic inflammatory demyelinating polyneuropathies
• Polyneuropathies associated with peripheral nerve autoantibodies
• AIDS
INHERITED NEUROPATHIES
• Neuropathies with biochemical markers: Refsum’s disease, Bassen- Kornzweig disease, Tangier disease, metachromatic leukodystrophy, Krabbe’s disease, adrenomyeloneuropathy,
Fabry’s disease
• Neuropathies without biochemical markers or systemic involvement: hereditary motor neuropathy, hereditary sensory neuropathy, hereditary sensorimotor neuropathy
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