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Symptoms and Signs – Differential Diagnosis of Thyroid function tests
Normal T4, T3 and TSH: Euthyroid
Normal T4 and T3, reduced TSH: Sub-clinical hyperthyroidism, same causes as overt
hyperthyroidism
Normal T4 and T3, Raised TSH: Subclinical hypothyroidism, same causes as overt
hypothyroidism
Reduced T4 and T3, raised TSH: Primary hypothyroidism (See Hypothyroidism}
Reduced T4 and T3, reduced or normal TSH: Secondary hypothyroidism (See Hypopituitarism},
sick euthyroid syndrome (systemic illness, esp. hospitalized patients}
Raised T4 and T3, reduced TSH: Primary hyperthyroidism (See Hyperthyroidism}
Raised T4 and T3, normal or Raised j TSH: Secondary hyperthyroidism (pituitary TSHoma},
resistance to thyroid hormone
Raised T4 and T3, normal TSH: i Serum thyroxine-binding globulin
Familial dysalbuminaemic hyperthyroxinaemia Anti-T4 antibodies
Normal T4, T3 and TSH: Euthyroid
Normal T4 and T3, reduced TSH: Sub-clinical hyperthyroidism, same causes as overt
hyperthyroidism
Normal T4 and T3, Raised TSH: Subclinical hypothyroidism, same causes as overt
hypothyroidism
Reduced T4 and T3, raised TSH: Primary hypothyroidism (See Hypothyroidism}
Reduced T4 and T3, reduced or normal TSH: Secondary hypothyroidism (See Hypopituitarism},
sick euthyroid syndrome (systemic illness, esp. hospitalized patients}
Raised T4 and T3, reduced TSH: Primary hyperthyroidism (See Hyperthyroidism}
Raised T4 and T3, normal or Raised j TSH: Secondary hyperthyroidism (pituitary TSHoma},
resistance to thyroid hormone
Raised T4 and T3, normal TSH: i Serum thyroxine-binding globulin
Familial dysalbuminaemic hyperthyroxinaemia Anti-T4 antibodies
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