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Symptoms and Signs – Differential Diagnosis of Ulcers: mouth, genital, leg
Mouth
Trauma, aphthous ulcers
Gastrointestinal diseases: Crohn's disease, coeliac disease
Infection: herpes simplex, acute ulcerative stomatitis (Vincent's angina),
candidiasis TB, syphilis (rare)
Exclude: leukaemia, agranulocytosis
Inflammatory: Behc;et's disease, reactive arthritis, SLE
Skin diseases: pemphigus, pemphigoid, erythema multiforme, lichen planus Malignancy: squamous cell carcinoma
Other: Strachan's syndrome
Genital
Infection: Painful: herpes simplex, Haemophilus ducreyi (chancroid) Painless: Syphilis (Treponema pallidum), Lymphogranuloma venereum (Chlamydia trachomatis), Granuloma inguinale (Calymmatobacterium granulomatis)
Behc;et's disease
Crohn's disease
Reiter's syndrome
Erythroplasia of Queyrat, squamous cell carcinoma Trauma
Other genital rashes: fixed drug eruption, eczema, psoriasis, scabies
Orogenital
Infection: herpes simplex, syphilis
Inflammatory diseases: Behc;et's disease, Reiter's syndrome Skin diseases: pemphigus, erythema multiforme
GI: Crohn's disease
Other: Strachan's diseases
Leg
Venous: superficial venous insufficiency, DVT
Arterial: atherosclerosis
Diabetic: ischaemic and neuropathic
Vasculitis: rheumatoid arthritis, primary vasculities, e.g. polyarteritis nodosa Sickle cell anaemia
Pressure
Pyoderma gangrenosum
Malignancy
Mouth
Trauma, aphthous ulcers
Gastrointestinal diseases: Crohn's disease, coeliac disease
Infection: herpes simplex, acute ulcerative stomatitis (Vincent's angina),
candidiasis TB, syphilis (rare)
Exclude: leukaemia, agranulocytosis
Inflammatory: Behc;et's disease, reactive arthritis, SLE
Skin diseases: pemphigus, pemphigoid, erythema multiforme, lichen planus Malignancy: squamous cell carcinoma
Other: Strachan's syndrome
Genital
Infection: Painful: herpes simplex, Haemophilus ducreyi (chancroid) Painless: Syphilis (Treponema pallidum), Lymphogranuloma venereum (Chlamydia trachomatis), Granuloma inguinale (Calymmatobacterium granulomatis)
Behc;et's disease
Crohn's disease
Reiter's syndrome
Erythroplasia of Queyrat, squamous cell carcinoma Trauma
Other genital rashes: fixed drug eruption, eczema, psoriasis, scabies
Orogenital
Infection: herpes simplex, syphilis
Inflammatory diseases: Behc;et's disease, Reiter's syndrome Skin diseases: pemphigus, erythema multiforme
GI: Crohn's disease
Other: Strachan's diseases
Leg
Venous: superficial venous insufficiency, DVT
Arterial: atherosclerosis
Diabetic: ischaemic and neuropathic
Vasculitis: rheumatoid arthritis, primary vasculities, e.g. polyarteritis nodosa Sickle cell anaemia
Pressure
Pyoderma gangrenosum
Malignancy
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