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​Symptoms and Signs – Differential Diagnosis of Erythema Nodosum
• Fat necrosis associated with pancreatitis
• Insect bites
• Lupus panniculitis
• Necrobiosis lipoidica
• Post-traumatic ecchymoses
• Scleroderma
• Subcutaneous granuloma
• Vasculitis
• Weber-Christian disease
• α1-Antitrypsin deficiency
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​Symptoms and Signs – Differential Diagnosis of Erythroderma
• Atopic eczema
• Cutaneous T-cell lymphoma
• Drug eruption (sulfonamides, allopurinol, anticonvulsants,penicillins)
• Fungal infection
• Lichen planus
• Norwegian (crusted) scabies
• Pityriasis rubra pilaris
• Seborrheic dermatitis
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​Symptoms and Signs – Differential Diagnosis of  Esophageal Cancer
• Achalasia of the esophagus
• Barrett’s esophagus
• Diffuse esophageal spasm
• Esophageal rings and webs
• Gastroesophageal reflux disease (GERD)
• Scleroderma of the esophagus
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​Symptoms and Signs – Differential Diagnosis of Esophagitis
• Aphthous ulcers
• Candidiasis
• Cytomegalovirus
• Gastroesophageal reflux
• Herpes simplex virus
• HIV infection, acute
• Mucositis from cancer chemotherapy
• Mucositis from radiation therapy
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​Symptoms and Signs – Differential Diagnosis of Esotropia
• Wernicke’s encephalopathy
• Thyroid myopathy
• Pseudo–sixth nerve palsy
• Posterior internuclear ophthalmoplegia
• Myasthenia gravis
• Medial rectus entrapment (e.g., blowout fracture)
• Congenital
• Chiari malformation
• Accommodative esotropia
• Abducens palsy
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​Symptoms and Signs – Differential Diagnosis of  Essential Tremor
• Wilson’s disease: wing-beating tremor that is most pronounced with shoulders abducted, elbows flexed, and fingers pointing toward each other. There are usually other neurologic abnormalities, including dysarthria, dystonia, and Kayser- Fleischer rings on ophthalmologic examination.
• Parkinson’s disease: tremor is usually asymmetric, especially early in the disease, and it is predominantly a resting tremor. Patients with Parkinson’s disease will also have increased tone, decreased facial expression, slowness of movement, and shuffling gait.
• Drug induced: many drugs enhance normal, physiologic tremor. These include caffeine, nicotine, lithium, levothyroxine, β- adrenergic bronchodilators, valproate, and selective serotonin reuptake inhibitors (SSRIs).
• Cerebellar tremor: an intention tremor that increases at the end of a goal-directed movement (such as finger to nose testing). Other associated neurologic abnormalities include ataxia, dysarthria, and difficulty with tandem gait.
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​Symptoms and Signs – Differential Diagnosis of  Exanthems
• Varicella
• Staphylococcal scalded skin
• Scarlet fever
• Rubella
• Roseola exanthema
• Rocky Mountain spotted fever
• Meningococcemia
• Measles
• Kawasaki’s disease
• Erythema infectiosum (fifth disease)
• Epstein-Barr virus
• Enterovirus
• Adenovirus
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