Dermatology - Drug Induced Pustular Rash

Dermatology - Drug Induced Pustular Rash 
Pustular Rash Caused by Drug (Adverse Cutaneous Drug Reactions) 

Acute generalized exanthematous pustulosis (AGEP) is a febrile eruption with an estimated yearly frequency of 1-2 million cases. It is frequently linked to leukocytosis. Skin lesions may not show for one to three weeks following drug administration; in patients who have already been sensitized, skin signs may manifest in two to three days.

Elevated blood neutrophils and fever are frequent. After less than 15 days, there is spontaneous resolve, which is followed by generalized desquamation around two weeks later.
Damage
Nonfollicular sterile pustules can be randomly distributed or aggregated, typically beginning in the skin folds and/or on the face, and they appear on a diffuse, edematous erythema.

Clinical diagnosis and differential diagnosis include subcorneal pustular dermatosis (Sneddon-Wilkinson disease), pustular psoriasis, and the hypersensitivity syndrome reaction with pustulation. Iodides, bromides, adrenocorticotropic hormone (ACTH), glucocorticoids, isoniazid, androgens, lithium, actinomycin D, and phenytoin are linked to acneiform pustular eruptions. The EGFR tyrosine kinase inhibitors erlotinib, gefitinib, cetuximab, and panitumumab cause non-acneiform pustules that typically appear on the face but can also occur in unexpected locations including the arms and legs. These pustules are also typically monomorphous. Usually, comedones are not present.

Stop using the offending medication and give the patient supportive treatment.