​Dermatology - Epidermolytic Hyperkeratosis

​Dermatology - Epidermolytic Hyperkeratosis 
An autosomal dominant mutation of keratin 1 and 10, the genes encoding keratins involved in epidermal differentiation, results in epidermolytic hyperkeratosis.

Blisters can be localized or widespread when epidermolytic hyperkeratosis first appears, and with time, the condition develops into keratotic and verrucous blisters.
Like rancid butter, there's a disagreeable condition that goes along with it. There are recurring pyogenic infections. There are defined regions of skin that appear normal as a result of the shedding of hyperkeratotic tumors.
Clinical presentation and family history are used to make the diagnosis.

Systemic acitretin or isotretinoin, topical alpha-hydroxyacids, cause greater production of blisters at first but significantly improve the skin over time. Pay close attention to dosage, keep an eye out for adverse effects, and follow any restrictions.