Dermatology - Pemphigoid Gestationis

Dermatology - Pemphigoid Gestationis
Pemphigoid gestationis is an uncommon, itchy, and diverse inflammatory blistering skin disorder that occurs during pregnancy and the period after childbirth. The condition can be worsened by the administration of drugs that contain estrogen and progesterone.
Pemphigoid gestationis often initiates between the fourth and seventh month of pregnancy, however it can also manifest in the first trimester and shortly after childbirth. May reoccur in subsequent pregnancies; if it does, it is probable to initiate earlier. There has been a marginal rise in the occurrence of preterm and small-for-gestational-age newborns. Several reports have indicated a notable occurrence of fetal death and early deliveries, whereas others have indicated no rise in fetal mortality.

A highly itchy rash starts primarily on the belly but may also appear on other parts of the body, while the mucous membranes are unaffected. The lesions range from red, swollen bumps and raised hives to fluid-filled blisters and tight blisters.

The diagnosis is established through clinical examination and can be verified by the detection of IgG antibasal membrane antibodies using the ELISA method.

Prednisone, administered at a dosage of 20-40 mg per day, has proven to be helpful. In certain cases, greater doses may be necessary. The dosage should be gradually reduced throughout the postpartum period.