Infectious Diseases and Microbiology - Ebola Hemorrhagic Fever ( Marburg and Ebola Viruses)

​Infectious Diseases and Microbiology - Ebola Hemorrhagic Fever ( Marburg and Ebola Viruses) 
Ebola Hemorrhagic Fever 
Serious hemorrhagic fever is caused by filoviruses such as the Marburg and Ebola viruses. Direct contact with bodily fluids tainted with the virus causes transmission. The fatality rate from the Marburg and Ebola viruses is about 90%. It's uncertain where the viruses originate naturally.
 
Abdominal pain, vomiting, and diarrhea are the next symptoms that accompany a quick onset of fever, headache, and joint and muscle pain, which is known as severe hemorrhagic fever. When bleeding occurs into the skin, mucous membranes, or visceral organs, the symptoms are worse. Shock and multiple organ failure cause death.

The viruses begin by infecting macrophages, then they travel throughout the body through the lymphatics and blood, infecting and necrotizing the spleen, liver, and lymph nodes. Vascular permeability, bleeding, and shock are brought on by tissue damage and elevated cytokine levels.

Viral antigens and viral RNA are detected by immunoassay and PCR, respectively, while virus-specific IgM or IgG is found by serology.

Ebola and Marburg hemorrhagic fever have no known cure or vaccine. In order to avoid direct contact with the patient and their bodily fluids, barrier measures and the isolation of suspected or confirmed infections are employed.