​Infectious Diseases and Microbiology - Primary Meningoencephalitis Amebic (Naegleria fowleri)

​Infectious Diseases and Microbiology - Primary Meningoencephalitis Amebic 
(Naegleria fowleri)
Physical: An opportunistic, free-living soil ameba.
By swimming in tainted warm fresh water, trophozoite infection is the mode of transmission to people.
An opportunistic, highly lethal meningoencephalitis caused by clinical N fowleri is marked by a fast-acting fever, stiff neck, headache, disorientation, vomiting, and changes in taste and smell perceptions.
Rapid progression results in a coma and death in 4-6 days.
 Trophozoites penetrate the nasal mucosa and use the crebriform plate to access the central nervous system.
Cerebrospinal fluid examined under a microscope reveals neutrophils, erythrocytes, and trophozoites.
On a lawn of gram-negative rods, which are their food source, amebae can be cultivated.
Few people survive this sickness, which is extremely deadly. There has been some success with amphotericin B treatment in conjunction with rifampin and micoazole.

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