Infectious Diseases and Microbiology - Roseola, Exanthem subitum ( Herpesvirus 6 and Herpesvirus 7)

​Infectious Diseases and Microbiology - Roseola, Exanthem subitum ( Herpesvirus 6 and Herpesvirus 7) 
Human herpesvirus 6 (HHV-6) causes exanthem subitum, or roseola, while human herpesvirus 7 (HHV-7) accounts for roughly 10% of cases. HHV-6 and HHV-7 are contracted in infancy and spread through saliva; 60–90% of adult individuals have viral antibody seropositivity.
 

A rash that extends from the trunk to the extremities appears after a high fever that lasts for two to five days. Seizures that are feverish with or without rash are possible in more severe cases. Reactivation of latent HHV-6 or HHV-7 is linked to hepatitis, pneumonia, encephalitis, and graft rejection in immunocompromised people (transplant recipients, AIDS patients).

T cells are infected and become latently infected by HHV-6 and HHV-7. Immunocompromised people reactivate the virus, and HHV-6 may play a role in the pathophysiology of AIDS.

PCR and serological techniques are used to identify HHV-6 and HHV-7.
 There are currently no vaccinations or specialized antiviral treatments for HHV-6 or HHV-7 infections.

---