Pathology - Amyotrophic Lateral Sclerosis
Pathophysiology Lou Gehrig's disease, is also commonly known as amyotrophic lateral sclerosis . The distinct feature of this disease lies in its manifestation of symptoms affecting both upper and lower motor neurons, which can be attributed to involvement of the corticospinal tract fibers. The symptoms of upper motor neurons include spasticity, positive Babinski sign, and hyperreflexia. Findings related to lower motor neurons include atrophy brought on by muscular denervation and fasciculations. This illness has been linked to mutations in superoxide dismutase, a catalyst with antioxidant properties. Progressive involvement of the brain stem might result in aphasia and dysphagia. The prognosis is bleak; respiratory failure usually results in death within a few years of diagnosis.
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