Pathology - Chronic Pancreatitis
Pathophysiology There is a connection between chronic pancreatic insufficiency and chronic pancreatitis. Exocrine pancreatic insufficiency causes maldigestion and malabsorption of food, which leads to diarrhea and nasty feces. The loss of endocrine pancreatic function is indicated by hyperglycemia. Malnutrition and a particular decrease of B12 absorption, which requires pancreatic enzymes, can cause anemia. Despite the usual acute spike in blood lipase and amylase due to pancreatitis, this patient has a little amount of functional pancreatic tissue mass because to fibrosis and is in the late stages of chronic illness. The most prevalent cause of pathogenesis is chronic alcohol consumption, although there are numerous additional factors as well, such as gallstone disease, immunological disorders, and inherited diseases like cystic fibrosis. It is believed that oxidative stress, toxicity from alcohol metabolism, duct blockage, and necrosis-fibrosis responses that occur after acute inflammation are responsible for the gland's destruction. Inflammation results from the gland's trypsinogen being activated improperly. Because of the pancreatic duct blockage, ischemia, necrosis, and inflammation, pain is a common observation. Imaging frequently reveals pancreatic duct dilating.
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