Pathology - Crohn's disease
Pathophysiology There are two main kinds of these chronic inflammatory disorders: ulcerative colitis (UC) and Crohn's disease (CD). An aberrant immune response to the normal gut flora is the outcome of a complex interplay of genetic, microbial, and immunologic variables that leads to the pathogenesis of inflammatory bowel disease (IBD). Leukocytosis, elevated C-reactive protein, and fecal leukocytes are examples of inflammatory markers present in this patient along with a favorable family history and chronicity. Clinical characteristics and immunologic profiles of CD and UC are different: In contrast to CD, which is a transmural illness characterized by the development of stenosis, fistulas, and gut obstruction sometimes accompanied by widely dispersed afflicted areas, UC is confined to the mucosal layer, begins in the rectum, and advances proximally in a confluent rather than dispersed way. Together with CT imaging, the patient's clinical symptoms point to isolated ileocecal illness that is more consistent with CD than UC. Fecal fat is a sign of small bowel involvement-related malabsorption. Tympany and distention suggest a possible bowel blockage.
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