Pathology - Goodpasture Syndrome

Pathology - Goodpasture Syndrome
Resulting from the presence of antibodies targeting the glomerular basement membrane (a type II hypersensitivity reaction)
Prevalent among males in the age range of 20 to 30 years.
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Pulmonary organ: Intra-alveolar hemorrhages refer to bleeding within the small air sacs of the lungs. Fibrosis thickening of the septa indicates the thickening of the walls that separate these air sacs. Hemosiderin-laden macrophages are cells within the air sacs that contain iron pigment due to the presence of blood.
Kidney: This condition, known as rapidly progressive crescentic glomerulonephritis, occurs when macrophages, proliferating parietal cells, and fibrin come together to create crescents in Bowman space. These crescents eventually lead to the destruction of Bowman space and the compression of the glomerular capillaries.
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Immunofluorescence investigations: Immunoglobulins are deposited in a linear pattern along the glomerular basement membranes (GBMs) of the alveoli.
The patient is experiencing hemoptysis, as well as symptoms of nephritic syndrome including edema, hypertension, and hematuria.
Laboratory results indicate the presence of Anti-GBM antibodies and iron deficient anemia.
Plasmapheresis is a medical procedure used to remove harmful substances from the blood. Corticosteroids and cyclophosphamide are medications that may be used to treat the condition. Hemodialysis may be necessary if the patient experiences renal failure.
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Anti GBM glomerulonephritis is defined by the presence of nephritic syndrome, which is caused by the deposition of anti GBM antibodies in the kidney. It is important to note that this condition does not affect the lungs.