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Pathology - Hashimoto Thyroiditis
Hashimoto Thyroiditis is an autoimmune illness.
Incidence is higher in middle-aged women, persons with a family history of Hashimoto or other autoimmune disorders, and those who are HLA-DRS- and BLABS-positive.
Pathology
Gross: Symmetrical thyroid hypertrophy resulting in a goiter.
The thyroid gland shows infiltration by lymphocytes and plasma cells, development of germinal centers, atrophic follicles, and Hurthle cells (epithelial cells with eosinophilic cytoplasm) under microscopic examination.
Symptoms and signs
Temporary excessive thyroid hormone levels, then decreased thyroid hormone levels.
Laboratory results: Autoantibodies target TG, thyroid peroxidase, TSH receptors, and/or iodine receptors.
Therapy: Synthetic levothyroxine.
Riedel thyroiditis is an uncommon form of thyroiditis marked by gradual fibrosis of the thyroid gland that spreads into other structures in the neck. The condition presents as a painless goiter that is firm, accompanied by difficulty swallowing or hoarseness. Approximately 30% of people will also experience hypothyroidism. Treatment involves partial thyroidectomy and corticosteroids.
Hashimoto Thyroiditis is an autoimmune illness.
Incidence is higher in middle-aged women, persons with a family history of Hashimoto or other autoimmune disorders, and those who are HLA-DRS- and BLABS-positive.
Pathology
Gross: Symmetrical thyroid hypertrophy resulting in a goiter.
The thyroid gland shows infiltration by lymphocytes and plasma cells, development of germinal centers, atrophic follicles, and Hurthle cells (epithelial cells with eosinophilic cytoplasm) under microscopic examination.
Symptoms and signs
Temporary excessive thyroid hormone levels, then decreased thyroid hormone levels.
Laboratory results: Autoantibodies target TG, thyroid peroxidase, TSH receptors, and/or iodine receptors.
Therapy: Synthetic levothyroxine.
Riedel thyroiditis is an uncommon form of thyroiditis marked by gradual fibrosis of the thyroid gland that spreads into other structures in the neck. The condition presents as a painless goiter that is firm, accompanied by difficulty swallowing or hoarseness. Approximately 30% of people will also experience hypothyroidism. Treatment involves partial thyroidectomy and corticosteroids.
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